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Biomedicine

A homozygous G insertion in MPLKIP leads to TTDN1 with the...

Medical Genetics: Background Trichothiodystrophy nonphotosensitive 1 (TTDN1) is a disease with mental retardation, brittle hair. Some cases of the diseases are caused by mutations of the...

Adaptive filtering of physiological noises in fNIRS data

BioMedical Engineering: The study presents a recursive least-squares estimation method with an exponential forgetting factor for noise removal in functional near-infrared spectroscopy data and extraction...

Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/β-catenin...

Nanobiotechnology: Background Fabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention. Methods In a previous study, novel lanthanum phosphate...

Exploring the OncoGenomic Landscape of cancer

Genome Medicine: Background The widespread incorporation of next-generation sequencing into clinical oncology has yielded an unprecedented amount of molecular data from thousands of patients. A main...

Horizontal transfer of BovB and L1 retrotransposons in eukaryotes

Genome Biology Background Transposable elements (TEs) are mobile DNA sequences, colloquially known as jumping genes because of their ability to replicate to new genomic locations. TEs...

Functional characterization of enhancer evolution in the primate lineage

Genome Biology Background Enhancers play an important role in morphological evolution and speciation by controlling the spatiotemporal expression of genes. Previous efforts to understand the evolution...

An integrative functional genomics framework for effective identification of novel regulatory...

Genome Medicine Abstract Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A...

Role of the HIV-1 envelope transmembrane domain in intracellular sorting

Cell Biology Abstract Background The envelope protein of lentiviruses are type I transmembrane proteins, and their transmembrane domain contains conserved potentially charged residues. This highly unusual feature...

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor...

Genome Medicine Abstract While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck....

From somatic variants towards precision oncology: Evidence-driven reporting of treatment options...

Genome Medicine Abstract Background A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting...

Readiness for antimicrobial resistance (AMR) surveillance in Pakistan; a model for...

Antimicrobial Resistance & Infection Control: Abstract Background Limited capacity of laboratories for antimicrobial susceptibility testing (AST) presents a critical diagnostic bottleneck in resource limited countries. This paper...

A functional magnetic resonance imaging investigation of visual hallucinations in the...

Behavioral and Brain Functions Hina Abid, Fayyaz Ahmad, Soo Y. Lee, Hyun W. Park, Dongmi Im, Iftikhar Ahmad and Safee U. Chaudhary | ©  The Author(s) 2016 Abstract Purpose Human beings frequently experience fear, phobia, migraine and hallucinations, however, the cerebral mechanisms underpinning these conditions...

Nanomedicine : „Russian doll“ polymer vesicles mimic cell structure

Nanomedicine faces two main challenges: controlling the synthesis of extremely small vectors containing one or several active ingredients and releasing these agents in the...

Defekte Erbgut-Verpackung bei bösartigem Hirntumor

Glioblastome gelten als besonders aggressive Hirntumore. In einem Forschungsverbund wurden bei dieser Erkrankung nun erstmals Genveränderungen entdeckt, die sich auf die Funktion der DNA-Verpackungsproteine...

Entscheidender Schritt für regenerative Wasserstoffherstellung: RUB-Forscher berichten

RUB-Forscher haben in Kooperation mit Kollegen der Pennsylvania State University ein biologisches System konstruiert, das mit Lichtenergie effizient Wasserstoff herstellt. Schlüssel zum Erfolg war...

New Material Promises Faster Electronics

The novel material graphene makes faster electronics possible. Scientists at the Faculty of Electrical Engineering and Information Technology at the Vienna University of Technology...

Leberzellen aus embryonalen und adulten Stammzellen unterscheiden sich kaum

Induzierte pluripotente Stammzellen aus fötalen Hautzellen und embryonale Stammzellen besitzen vergleichbares Potenzial zur Bildung von Leberzellen (mpg/ehj) - Viele Patienten mit chronischen Lebererkrankungen können derzeit...

Künstliche Photosynthese mit formvollendeten Lichtantennen

Regensburger Physiker weisen nach: Effizienz ist von der Morphologie der Nanoteilchen abhängig (idw/ehj) - Unsere Versuche, Sonnenenergie zu nutzen, sind bislang noch nicht wirklich effektiv....

Better imaging from bench to bedside

Euro-BioImaging, a project which launches its preparatory phase today, aims to provide scientists throughout Europe with open access to state-of-the-art imaging technologies at all...

Genmutation führt zu Taubheit und Herzstörung

Auf den ersten Blick haben Hören und Herzrhythmus wenig miteinander zu tun. Dass die Funktionen beider Organe sehr wohl eng gekoppelt sind, zeigt eine...

Wie widerstehen DNA-Bestandteile schädlicher UV-Einwirkung?

Das genetische Material der DNA enthält Schutzmechanismen, um sich vor dem UV-Licht der Sonneneinstrahlung zu schützen. Dies ist von essentieller Bedeutung, da es ohne...

Ein Paar und doch kein Paar

Riesen-Moleküle im Überlagerungszustand. In menschlichen Beziehungsdingen ist es so: Entweder man ist ein Paar oder man ist kein Paar - ein klassisches Dilemma mit...

Zellfunktionen mit Lichtsensoren steuern

Regensburger Forschern gelingt Durchbruch beim Verständnis der Funktionsweise lichtregulierbarer Schalter in Pflanzen. (idw/ehj) - Zellen sind Grundbausteine aller Organismen. Sie können durch äußere Reize –...

Researchers insert identification codes into mouse embryos

Researchers from the Department of Cell Biology, Physiology and Immunology at Universitat Autònoma de Barcelona (UAB), in collaboration with researchers from the Institute of...
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