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Medicine

Role of the HIV-1 envelope transmembrane domain in intracellular sorting

Cell Biology Abstract Background The envelope protein of lentiviruses are type I transmembrane proteins, and their transmembrane domain contains conserved potentially charged residues. This highly unusual feature...

Mitochondrial dysfunction and autism: comprehensive genetic analyses of children with autism...

Behavioral and Brain Functions Abstract Background The etiology of autism spectrum disorders (ASD) is very heterogeneous. Mitochondrial dysfunction has been described in ASD; however, primary mitochondrial disease...

Neural correlates of interference resolution in the multi-source interference task: a...

Behavioral and Brain Functions Abstract Background Interference resolution refers to cognitive control processes enabling one to focus on task-related information while filtering out unrelated information. But the...

Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay...

Abstract Background Decapping of mRNA is an important step in the regulation of mRNA turnover and therefore of gene expression, which is a key process controlling...

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor...

Genome Medicine Abstract While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck....

Tracking progressive pathological and functional decline in the rTg4510 mouse model...

Alzheimer's Research & Therapy: Abstract Background The choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical translation...

Effects of dosimetric inadequacy on local control and toxicities in the...

Chinese Journal of Cancer: Abstract Background To protect neurological tissues, underdosing occurs in most cases of T4 nasopharyngeal carcinoma (NPC) with intracranial extension. In this study, we...

Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is...

Cancer Cells: Abstract Objective To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived exosomes. Methods Exosomes...

The association of sleep disordered breathing with left ventricular remodeling in...

Cardiovascular Disorders: Abstract Background There is still insufficient knowledge on the potential effect of mild to moderate sleep-disordered breathing (SDB) that is widely prevalent, often asymptomatic, and...

Selective impairments of alerting and executive control in HIV-infected patients: evidence...

Behavioral and Brain Functions: Abstract: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has...

Molecular chess? Hallmarks of anti-cancer drug resistance

Abstract Background The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is...

Microparticles shed from multidrug resistant breast cancer cells provide a parallel...

Abstract Background Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune...

Does Congenital Deafness Affect the Structural and Functional Architecture of Primary...

Abstract Deafness results in greater reliance on the remaining senses. It is unknown whether the cortical architecture of the intact senses is optimized to compensate...

Skeleton-based cerebrovascular quantitative analysis

Xingce Wang, Enhui Liu†, Zhongke Wu, Feifei Zhai†, Yi-Cheng Zhu, Wuyang Shui and Mingquan Zhou ©  The Author(s) 2016 Abstract Background Cerebrovascular disease is the most common cause of death worldwide, with millions of deaths annually. Interest is increasing toward understanding the...

Quantitative analysis of axon collaterals of single pyramidal cells of the...

Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda,Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda © The Author(s) 2017 Abstract Background The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the...

Integrated therapy for HIV and tuberculosis

Abstract Tuberculosis (TB) has been the most common opportunistic infection and cause of mortality among HIV-infected patients, especially in resource-limited countries. Clinical manifestations of TB...

Transient left atrial dysfunction is a feature of Takotsubo syndrome

Abstract Background Takotsubo syndrome (TTS) is characterized by a transient left and/or right ventricular dysfunction as a consequence of a distinctive pattern of regional wall motion...

Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in...

Abstract Substantial data indicate that amyloid-β (Aβ), the major component of senile plaques, plays a central role in Alzheimer’s Disease and indeed the assembly of...

Review of RyR1 pathway and associated pathomechanisms

Abstract Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle important for excitation-contraction coupling. Mutations in the RYR1 gene yield RyR1 protein...

Scripps Florida Scientists Identify Novel Compound to Alleviate Pain and Itch

In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a possible drug candidate that suppresses pain...

Environmental scientist’s early warning indicators win the prize

Promising environmental researcher David Seekell has been awarded a prestigious prize: the Science and SciLifeLab Prize for Young Scientists. He was awarded the prize...

Short-term memory is based on synchronized brain oscillations

Scientists have now discovered how different brain regions cooperate during short-term memory. Holding information within one’s memory for a short while is a seemingly...

Improving Medical Treatment Requires a Risk-based Approach to the Regulation of...

Current EU legislation represents a major hurdle to improving medical treatment due to the straight-jacket of EU legislation that the 2001 Clinical Trials Directive...

Barrett’s patients who smoke twice as likely to develop oesophageal cancer

Smoking doubles the risk of developing oesophageal cancer in people with Barrett’s Oesophagus, according to scientists at Queen’s University Belfast and the Northern Ireland...