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Medicine

Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

Alzheimer's Research & Therapy: Background FDG-PET hypometabolism patterns are indicative of different neurodegenerative conditions, even from the earliest disease phase. This makes FDG-PET a valuable tool...

A modular analysis of microglia gene expression, insights into the aged...

Genomics: Background Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of the...

A case of methylprednisolone treatment for metronidazole-induced encephalopathy

Neurology Background: Metronidazole, a common antimicrobial agent, can induce encephalopathy in rare cases. After discontinuing metronidazole, most patients show clinical improvement. However, in...

Managing emerging transnational public health security threats: lessons learned from the...

Globalization and Health: Background Pandemics pose significant security/stability risks to nations with...

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

Medical Genetics: Background HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is relevant to establish resistance to therapeutic approaches. The use of compounds direct against hypoxia signaling...

COL6A1 mutation leading to Bethlem myopathy with recurrent hematuria: a case...

Neurology: Background Collagen VI-related myopathies are a spectrum of muscular diseases with features of muscle weakness and atrophy, multiple contractures of joints, distal hyperextensibility, severe respiratory...

Differential proteomics for studying action mechanisms of traditional Chinese medicines

Chinese Medicine:Differential proteomics, which has been widely used in studying of traditional Chinese medicines (TCMs) during the past 10 years, is a powerful tool to...

Does all single infarction have lower risk of stroke recurrence than...

Neurology: Background Single acute infarction (SAI) usually had lower risk of stroke recurrence than multiple acute infarctions (MAIs) in minor stroke. To evaluate whether all SAI...

A panel of 32 AIMs suitable for population stratification correction and...

Genetics: Background Association studies are useful to unravel the genetic basis of common human diseases. However, the presence of undetected population structure can lead to both...

A homozygous G insertion in MPLKIP leads to TTDN1 with the...

Medical Genetics: Background Trichothiodystrophy nonphotosensitive 1 (TTDN1) is a disease with mental retardation, brittle hair. Some cases of the diseases are caused by mutations of the...

The eye of the beholder: orbital metastases from midgut neuroendocrine tumors,...

Cancer Imaging: Background Metastases to the orbit occur rarely in midgut neuroendocrine tumor (NET) patients with only 20 cases reported to date. Patients typically...

Endometrial cancer: an overview of novelties in treatment and related imaging...

Cancer Imaging: Endometrial cancer is the most common gynaecologic malignancy in developed countries and its incidence is increasing. First-level treatment, if no contraindicated, is based...

Epidemiology of mechanically ventilated patients treated in ICU and non-ICU settings...

Critical Care: Background In most countries, patients receiving mechanical ventilation (MV) are treated in intensive care units (ICUs). However, in some countries, including Japan, many patients...

Adaptive filtering of physiological noises in fNIRS data

BioMedical Engineering: The study presents a recursive least-squares estimation method with an exponential forgetting factor for noise removal in functional near-infrared spectroscopy data and extraction...

Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/β-catenin...

Nanobiotechnology: Background Fabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention. Methods In a previous study, novel lanthanum phosphate...

Identification of novel compound heterozygous SPG7 mutations-related hereditary spastic paraplegia in...

Neurology: Background Autosomal recessive hereditary spastic paraplegias (ARHSPs) are a group of clinically and genetically heterogeneous neurodegenerative diseases with progressive spasticity and weakness in the lower...

Performance comparison of ventricular and arterial dP/dtmax for assessing left ventricular...

Critical Care: Background Maximal left ventricular (LV) pressure rise (LV dP/dtmax), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform...

Detection of gastric cancer and its histological type based on iodine...

Cancer Imaging: Background Computed tomography (CT) imaging is the most common imaging modality for the diagnosis and staging of gastric cancer. The aim of this study...

Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal...

Biomedical Science: Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors...

Delay in antibiotic therapy results in fatal disease outcome in murine...

Critical Care: Background Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are...

Dual-phase whole-heart imaging using image navigation in congenital heart disease

Medical Imaging: Background Dual-phase 3-dimensional whole-heart acquisition allows simultaneous imaging during systole and diastole. Respiratory navigator gating and tracking of the diaphragm is used with limited...

T cell dynamics and response of the microbiota after gene therapy...

Genome Medicine: Background Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene...

Transcranial direct current stimulation for the treatment of tinnitus: a review...

Neuroscience: Background Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous...

Fibronectin type III domain-containing protein 5 interacts with APP and decreases...

Molecular Brain: The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism...