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Medicine

Epidemiology of mechanically ventilated patients treated in ICU and non-ICU settings...

Critical Care: Background In most countries, patients receiving mechanical ventilation (MV) are treated in intensive care units (ICUs). However, in some countries, including Japan, many patients...

Adaptive filtering of physiological noises in fNIRS data

BioMedical Engineering: The study presents a recursive least-squares estimation method with an exponential forgetting factor for noise removal in functional near-infrared spectroscopy data and extraction...

Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/β-catenin...

Nanobiotechnology: Background Fabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention. Methods In a previous study, novel lanthanum phosphate...

Identification of novel compound heterozygous SPG7 mutations-related hereditary spastic paraplegia in...

Neurology: Background Autosomal recessive hereditary spastic paraplegias (ARHSPs) are a group of clinically and genetically heterogeneous neurodegenerative diseases with progressive spasticity and weakness in the lower...

Performance comparison of ventricular and arterial dP/dtmax for assessing left ventricular...

Critical Care: Background Maximal left ventricular (LV) pressure rise (LV dP/dtmax), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform...

Detection of gastric cancer and its histological type based on iodine...

Cancer Imaging: Background Computed tomography (CT) imaging is the most common imaging modality for the diagnosis and staging of gastric cancer. The aim of this study...

Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal...

Biomedical Science: Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors...

Delay in antibiotic therapy results in fatal disease outcome in murine...

Critical Care: Background Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are...

Dual-phase whole-heart imaging using image navigation in congenital heart disease

Medical Imaging: Background Dual-phase 3-dimensional whole-heart acquisition allows simultaneous imaging during systole and diastole. Respiratory navigator gating and tracking of the diaphragm is used with limited...

T cell dynamics and response of the microbiota after gene therapy...

Genome Medicine: Background Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene...

Transcranial direct current stimulation for the treatment of tinnitus: a review...

Neuroscience: Background Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous...

Fibronectin type III domain-containing protein 5 interacts with APP and decreases...

Molecular Brain: The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism...

Trends analysis for drug utilization in county public hospitals: a sample...

Health Services Research: Background Changes in the national drug policy always have impact on the drug utilization. In the context of China health care reform, what...

Structural and procedural barriers to health assessment for asylum seekers and...

Health Services Research: Background Health assessments (HAs) for newly arrived asylum seekers have become a regular practice in most EU countries, but what is performed, how...

Exploring the OncoGenomic Landscape of cancer

Genome Medicine: Background The widespread incorporation of next-generation sequencing into clinical oncology has yielded an unprecedented amount of molecular data from thousands of patients. A main...

New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis...

Genomics: Background Ural genetic family is a part of the Euro-American lineage of Mycobacterium tuberculosis and is endemic in Northern Eurasia (former Soviet Union ). These strains were...

Effects on the pulmonary hemodynamics and gas exchange with a speed...

Engineering OnLine: Rotary blood pumps (RBPs) are the newest generation of ventricular assist devices. Although their continuous flow characteristics have been accepted widely, more and...

Identification of a novel DNMT1 mutation in a Chinese patient with...

Neurology: DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It...

Functional EEG connectivity during competition

Neuroscience: Background Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since...

The impact of education on cortical thickness in amyloid-negative subcortical vascular...

Alzheimer's Research Background The protective effect of education has been well established in Alzheimer’s disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear....

MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker...

Alzheimer's Research Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers...

Complete genome sequence of Kocuria rhizophila BT304, isolated from the small...

Genome Background Members of the species Kocuria rhizophila, belonging to the family Micrococcaceae in the phylum Actinobacteria, have been isolated from a wide variety of natural...

Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in...

ImmunoTherapy of Cancer Background Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical...

Biochemical and molecular characterization of adult patients with type I Gaucher...

Medical Genetics Background Gaucher disease is a rare pan-ethnic disorder which occurs due to an increased accumulation of undegraded glycolipid glucocerebroside inside the cells’ lysosomes. A...