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Medicine

Effectiveness of a diabetes prevention program for rural women with prior...

Public Health Abstract Background In China, about 53.4 million women (11%) have type 2 diabetes (T2DM). Women with prior 2 (GDM) are at a high risk for...

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline...

Behavioral and Brain Functions Abstract Background With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life....

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures

Molecular Brain Abstract Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these...

Cellular stress response mechanisms of Rhizoma coptidis: a systematic review

Chinese Medicine Abstract Rhizoma coptidis has been used in China for thousands of years with the functions of heating dampness and purging fire detoxification. But the...

The impact of blood type O on mortality of severe trauma...

Critical Care Abstract Background Recent studies have implicated the differences in the ABO blood system as a potential risk for various diseases, including hemostatic disorders and hemorrhage....

Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in...

Chinese Medicine Abstract Background To evaluate the effect of Isorhynchophylline (IRN) on the learning and memory impairments induced by aluminum chloride (AlCl3) in mice. Methods Fifty male Balb-c mice...

Characterisation of Zika virus infection in primary human astrocytes

Neuroscience Abstract Background The recent Zika virus (ZIKV) outbreak has linked ZIKV with microcephaly and other central nervous system pathologies in humans. Astrocytes are among the first...

An integrative functional genomics framework for effective identification of novel regulatory...

Genome Medicine Abstract Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A...

Role of the HIV-1 envelope transmembrane domain in intracellular sorting

Cell Biology Abstract Background The envelope protein of lentiviruses are type I transmembrane proteins, and their transmembrane domain contains conserved potentially charged residues. This highly unusual feature...

Mitochondrial dysfunction and autism: comprehensive genetic analyses of children with autism...

Behavioral and Brain Functions Abstract Background The etiology of autism spectrum disorders (ASD) is very heterogeneous. Mitochondrial dysfunction has been described in ASD; however, primary mitochondrial disease...

Neural correlates of interference resolution in the multi-source interference task: a...

Behavioral and Brain Functions Abstract Background Interference resolution refers to cognitive control processes enabling one to focus on task-related information while filtering out unrelated information. But the...

Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay...

Abstract Background Decapping of mRNA is an important step in the regulation of mRNA turnover and therefore of gene expression, which is a key process controlling...

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor...

Genome Medicine Abstract While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck....

Tracking progressive pathological and functional decline in the rTg4510 mouse model...

Alzheimer's Research & Therapy: Abstract Background The choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical translation...

Effects of dosimetric inadequacy on local control and toxicities in the...

Chinese Journal of Cancer: Abstract Background To protect neurological tissues, underdosing occurs in most cases of T4 nasopharyngeal carcinoma (NPC) with intracranial extension. In this study, we...

Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is...

Cancer Cells: Abstract Objective To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived exosomes. Methods Exosomes...

The association of sleep disordered breathing with left ventricular remodeling in...

Cardiovascular Disorders: Abstract Background There is still insufficient knowledge on the potential effect of mild to moderate sleep-disordered breathing (SDB) that is widely prevalent, often asymptomatic, and...

Selective impairments of alerting and executive control in HIV-infected patients: evidence...

Behavioral and Brain Functions: Abstract: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has...

Molecular chess? Hallmarks of anti-cancer drug resistance

Abstract Background The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is...

Microparticles shed from multidrug resistant breast cancer cells provide a parallel...

Abstract Background Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune...

Does Congenital Deafness Affect the Structural and Functional Architecture of Primary...

Abstract Deafness results in greater reliance on the remaining senses. It is unknown whether the cortical architecture of the intact senses is optimized to compensate...

Skeleton-based cerebrovascular quantitative analysis

Xingce Wang, Enhui Liu†, Zhongke Wu, Feifei Zhai†, Yi-Cheng Zhu, Wuyang Shui and Mingquan Zhou ©  The Author(s) 2016 Abstract Background Cerebrovascular disease is the most common cause of death worldwide, with millions of deaths annually. Interest is increasing toward understanding the...

Quantitative analysis of axon collaterals of single pyramidal cells of the...

Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda,Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda © The Author(s) 2017 Abstract Background The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the...

Integrated therapy for HIV and tuberculosis

Abstract Tuberculosis (TB) has been the most common opportunistic infection and cause of mortality among HIV-infected patients, especially in resource-limited countries. Clinical manifestations of TB...