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MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker...

Alzheimer's Research Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers...

Complete genome sequence of Kocuria rhizophila BT304, isolated from the small...

Genome Background Members of the species Kocuria rhizophila, belonging to the family Micrococcaceae in the phylum Actinobacteria, have been isolated from a wide variety of natural...

Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in...

ImmunoTherapy of Cancer Background Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical...

Biochemical and molecular characterization of adult patients with type I Gaucher...

Medical Genetics Background Gaucher disease is a rare pan-ethnic disorder which occurs due to an increased accumulation of undegraded glycolipid glucocerebroside inside the cells’ lysosomes. A...

Protein interaction and functional data indicate MTHFD2 involvement in RNA processing...

Cancer & Metabolism: Background The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as...

Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway...

Immunology Background The involvement of inflammasome activation and macrophage polarization during the process of syphilis infection remains unknown. In this study, A series of experiments were...

The impact of blood type O on mortality of severe trauma...

Critical Care Abstract Background Recent studies have implicated the differences in the ABO blood system as a potential risk for various diseases, including hemostatic disorders and hemorrhage....

Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in...

Chinese Medicine Abstract Background To evaluate the effect of Isorhynchophylline (IRN) on the learning and memory impairments induced by aluminum chloride (AlCl3) in mice. Methods Fifty male Balb-c mice...

Characterisation of Zika virus infection in primary human astrocytes

Neuroscience Abstract Background The recent Zika virus (ZIKV) outbreak has linked ZIKV with microcephaly and other central nervous system pathologies in humans. Astrocytes are among the first...

An integrative functional genomics framework for effective identification of novel regulatory...

Genome Medicine Abstract Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A...

InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by...

Biology Abstract Background Candida albicans (C. albicans) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca2+ levels via the inositol 1,4,5-trisphosphate receptor (InsP3R) plays a...

Role of the HIV-1 envelope transmembrane domain in intracellular sorting

Cell Biology Abstract Background The envelope protein of lentiviruses are type I transmembrane proteins, and their transmembrane domain contains conserved potentially charged residues. This highly unusual feature...

Mitochondrial dysfunction and autism: comprehensive genetic analyses of children with autism...

Behavioral and Brain Functions Abstract Background The etiology of autism spectrum disorders (ASD) is very heterogeneous. Mitochondrial dysfunction has been described in ASD; however, primary mitochondrial disease...

Neural correlates of interference resolution in the multi-source interference task: a...

Behavioral and Brain Functions Abstract Background Interference resolution refers to cognitive control processes enabling one to focus on task-related information while filtering out unrelated information. But the...

Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay...

Abstract Background Decapping of mRNA is an important step in the regulation of mRNA turnover and therefore of gene expression, which is a key process controlling...

A longitudinal study on how implicit attitudes and explicit cognitions synergistically...

Psychology Abstract Background Strategies to promote physical activity (PA) focus mainly on changing or fostering explicit cognitions and are only modestly effective. Contemporary studies suggest that, as...

From somatic variants towards precision oncology: Evidence-driven reporting of treatment options...

Genome Medicine Abstract Background A comprehensive understanding of cancer has been furthered with technological improvements and decreasing costs of next-generation sequencing (NGS). However, the complexity of interpreting...

Rethinking the treatment of chronic fatigue syndrome—a reanalysis and evaluation of...

Psychology Abstract Background The PACE trial was a well-powered randomised trial designed to examine the efficacy of graded exercise therapy (GET) and cognitive behavioural therapy (CBT) for...

Association between baseline psychological attributes and mental health outcomes after soldiers...

Abstract Background Psychological health is vital for effective employees, especially in stressful occupations like military and public safety sectors. Yet, until recently little empirical work has...

Methods for enhancing the reproducibility of biomedical research findings using electronic...

BioData Mining   Abstract Background The ability of external investigators to reproduce published scientific findings is critical for the evaluation and validation of biomedical research by the wider...

Readiness for antimicrobial resistance (AMR) surveillance in Pakistan; a model for...

Antimicrobial Resistance & Infection Control: Abstract Background Limited capacity of laboratories for antimicrobial susceptibility testing (AST) presents a critical diagnostic bottleneck in resource limited countries. This paper...

The effect for Japanese workers of a self-help computerized cognitive behaviour...

Psychology: Abstract Background Computerized cognitive behaviour therapy (CCBT) programs can provide a useful self-help approach to the treatment of psychological problems. Previous studies have shown that CCBT...

The effect of recall, reproduction, and restudy on word learning: a...

Psychology: Abstract Background Certain manipulations, such as testing oneself on newly learned word associations (recall), or the act of repeating a word during training (reproduction), can lead...

Consequences of child emotional abuse, emotional neglect and exposure to intimate...

Psychology: Abstract Background Child maltreatment and eating disorders are significant public health problems. Yet, to date, research has focused on the role of child physical and sexual...

Tracking progressive pathological and functional decline in the rTg4510 mouse model...

Alzheimer's Research & Therapy: Abstract Background The choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical translation...