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Does all single infarction have lower risk of stroke recurrence than...

Neurology: Background Single acute infarction (SAI) usually had lower risk of stroke recurrence than multiple acute infarctions (MAIs) in minor stroke. To evaluate whether all SAI...

A panel of 32 AIMs suitable for population stratification correction and...

Genetics: Background Association studies are useful to unravel the genetic basis of common human diseases. However, the presence of undetected population structure can lead to both...

A homozygous G insertion in MPLKIP leads to TTDN1 with the...

Medical Genetics: Background Trichothiodystrophy nonphotosensitive 1 (TTDN1) is a disease with mental retardation, brittle hair. Some cases of the diseases are caused by mutations of the...

The eye of the beholder: orbital metastases from midgut neuroendocrine tumors,...

Cancer Imaging: Background Metastases to the orbit occur rarely in midgut neuroendocrine tumor (NET) patients with only 20 cases reported to date. Patients typically...

Endometrial cancer: an overview of novelties in treatment and related imaging...

Cancer Imaging: Endometrial cancer is the most common gynaecologic malignancy in developed countries and its incidence is increasing. First-level treatment, if no contraindicated, is based...

Epidemiology of mechanically ventilated patients treated in ICU and non-ICU settings...

Critical Care: Background In most countries, patients receiving mechanical ventilation (MV) are treated in intensive care units (ICUs). However, in some countries, including Japan, many patients...

New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis...

Genomics: Background Ural genetic family is a part of the Euro-American lineage of Mycobacterium tuberculosis and is endemic in Northern Eurasia (former Soviet Union ). These strains were...

Effects on the pulmonary hemodynamics and gas exchange with a speed...

Engineering OnLine: Rotary blood pumps (RBPs) are the newest generation of ventricular assist devices. Although their continuous flow characteristics have been accepted widely, more and...

Identification of a novel DNMT1 mutation in a Chinese patient with...

Neurology: DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It...

Functional EEG connectivity during competition

Neuroscience: Background Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since...

The impact of education on cortical thickness in amyloid-negative subcortical vascular...

Alzheimer's Research Background The protective effect of education has been well established in Alzheimer’s disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear....

MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker...

Alzheimer's Research Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers...

Complete genome sequence of Kocuria rhizophila BT304, isolated from the small...

Genome Background Members of the species Kocuria rhizophila, belonging to the family Micrococcaceae in the phylum Actinobacteria, have been isolated from a wide variety of natural...

Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in...

ImmunoTherapy of Cancer Background Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical...

Biochemical and molecular characterization of adult patients with type I Gaucher...

Medical Genetics Background Gaucher disease is a rare pan-ethnic disorder which occurs due to an increased accumulation of undegraded glycolipid glucocerebroside inside the cells’ lysosomes. A...

Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway...

Immunology Background The involvement of inflammasome activation and macrophage polarization during the process of syphilis infection remains unknown. In this study, A series of experiments were...

Emotion regulation and its relation to symptoms of anxiety and depression...

Psychology Background Symptoms of anxiety and depression are prevalent and highly comorbid in children, contributing to considerable impairment even at a subclinical level. Difficulties with emotion...

Horizontal transfer of BovB and L1 retrotransposons in eukaryotes

Genome Biology Background Transposable elements (TEs) are mobile DNA sequences, colloquially known as jumping genes because of their ability to replicate to new genomic locations. TEs...

Functional characterization of enhancer evolution in the primate lineage

Genome Biology Background Enhancers play an important role in morphological evolution and speciation by controlling the spatiotemporal expression of genes. Previous efforts to understand the evolution...

Sepsis is a preventable public health problem

Critical Care There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments...

Criminal justice measures for economic data harmonization in substance use disorder...

Health & Justice Background The consequences of substance use disorders (SUDs) are varied and broad, affecting many sectors of society and the economy. Economic evaluation translates...

Anti-inflammatory effects of minocycline are mediated by retinoid signaling

Neuroscience: Background Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data...

Low-cost customized cranioplasty using a 3D digital printing model: a case...

3D Printing in Medicine Abstract Background Cranial defects usually occur after trauma, neurosurgical procedures like decompressive craniotomy, tumour resections, infection and congenital defects. The purpose of cranial...

Utilizing a low-cost desktop 3D printer to develop a “one-stop 3D...

3D Printing in Medicine Abstract Background In the oral and maxillofacial surgery and dentistry fields, the use of three-dimensional (3D) patient-specific organ models is increasing, which has...

How group singing facilitates recovery from the symptoms of postnatal depression:...

Psychology Abstract Background Previous research has demonstrated that making music can enhance positive emotions as well as support positive psychological functioning. However, studies tend to be limited...