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An integrative functional genomics framework for effective identification of novel regulatory...

Genome Medicine Abstract Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A...

InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by...

Biology Abstract Background Candida albicans (C. albicans) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca2+ levels via the inositol 1,4,5-trisphosphate receptor (InsP3R) plays a...

Role of the HIV-1 envelope transmembrane domain in intracellular sorting

Cell Biology Abstract Background The envelope protein of lentiviruses are type I transmembrane proteins, and their transmembrane domain contains conserved potentially charged residues. This highly unusual feature...

Mitochondrial dysfunction and autism: comprehensive genetic analyses of children with autism...

Behavioral and Brain Functions Abstract Background The etiology of autism spectrum disorders (ASD) is very heterogeneous. Mitochondrial dysfunction has been described in ASD; however, primary mitochondrial disease...

Neural correlates of interference resolution in the multi-source interference task: a...

Behavioral and Brain Functions Abstract Background Interference resolution refers to cognitive control processes enabling one to focus on task-related information while filtering out unrelated information. But the...

Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay...

Abstract Background Decapping of mRNA is an important step in the regulation of mRNA turnover and therefore of gene expression, which is a key process controlling...

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Molecular chess? Hallmarks of anti-cancer drug resistance

Abstract Background The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is...

Microparticles shed from multidrug resistant breast cancer cells provide a parallel...

Abstract Background Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune...

Does Congenital Deafness Affect the Structural and Functional Architecture of Primary...

Abstract Deafness results in greater reliance on the remaining senses. It is unknown whether the cortical architecture of the intact senses is optimized to compensate...

Skeleton-based cerebrovascular quantitative analysis

Xingce Wang, Enhui Liu†, Zhongke Wu, Feifei Zhai†, Yi-Cheng Zhu, Wuyang Shui and Mingquan Zhou ©  The Author(s) 2016 Abstract Background Cerebrovascular disease is the most common cause of death worldwide, with millions of deaths annually. Interest is increasing toward understanding the...

Quantitative analysis of axon collaterals of single pyramidal cells of the...

Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda,Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda © The Author(s) 2017 Abstract Background The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the...

A functional magnetic resonance imaging investigation of visual hallucinations in the...

Behavioral and Brain Functions Hina Abid, Fayyaz Ahmad, Soo Y. Lee, Hyun W. Park, Dongmi Im, Iftikhar Ahmad and Safee U. Chaudhary | ©  The Author(s) 2016 Abstract Purpose Human beings frequently experience fear, phobia, migraine and hallucinations, however, the cerebral mechanisms underpinning these conditions...

Integrated therapy for HIV and tuberculosis

Abstract Tuberculosis (TB) has been the most common opportunistic infection and cause of mortality among HIV-infected patients, especially in resource-limited countries. Clinical manifestations of TB...

Transient left atrial dysfunction is a feature of Takotsubo syndrome

Abstract Background Takotsubo syndrome (TTS) is characterized by a transient left and/or right ventricular dysfunction as a consequence of a distinctive pattern of regional wall motion...

Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in...

Abstract Substantial data indicate that amyloid-β (Aβ), the major component of senile plaques, plays a central role in Alzheimer’s Disease and indeed the assembly of...

Scripps Florida Scientists Identify Novel Compound to Alleviate Pain and Itch

In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a possible drug candidate that suppresses pain...

Environmental scientist’s early warning indicators win the prize

Promising environmental researcher David Seekell has been awarded a prestigious prize: the Science and SciLifeLab Prize for Young Scientists. He was awarded the prize...

Short-term memory is based on synchronized brain oscillations

Scientists have now discovered how different brain regions cooperate during short-term memory. Holding information within one’s memory for a short while is a seemingly...

Improving Medical Treatment Requires a Risk-based Approach to the Regulation of...

Current EU legislation represents a major hurdle to improving medical treatment due to the straight-jacket of EU legislation that the 2001 Clinical Trials Directive...

Barrett’s patients who smoke twice as likely to develop oesophageal cancer

Smoking doubles the risk of developing oesophageal cancer in people with Barrett’s Oesophagus, according to scientists at Queen’s University Belfast and the Northern Ireland...

In lab, Pannexin1 restores tight binding of cells that is lost...

By studying tumor cell behavior in a novel “scaffold-free” 3-D system, researchers have determined that the protein Pannexin1 may play an important biomechanical role...

Nanomedicine : “Russian doll” polymer vesicles mimic cell structure

Nanomedicine faces two main challenges: controlling the synthesis of extremely small vectors containing one or several active ingredients and releasing these agents in the...

Defekte Erbgut-Verpackung bei bösartigem Hirntumor

Glioblastome gelten als besonders aggressive Hirntumore. In einem Forschungsverbund wurden bei dieser Erkrankung nun erstmals Genveränderungen entdeckt, die sich auf die Funktion der DNA-Verpackungsproteine...

Entscheidender Schritt für regenerative Wasserstoffherstellung: RUB-Forscher berichten

RUB-Forscher haben in Kooperation mit Kollegen der Pennsylvania State University ein biologisches System konstruiert, das mit Lichtenergie effizient Wasserstoff herstellt. Schlüssel zum Erfolg war...

Oxygen molecule survives to enormously high pressures

Using computer simulations, a RUB researcher has shown that the oxygen molecule (O2) is stable up to pressures of 1.9 terapascal, which is about...