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Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for...

Nanobiotechnology:Numerous first generation phosphorothioates (PS) and their derivatives have shown promise targeting mRNA for therapeutic applications and also gained market approval for their use...

Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

Alzheimer's Research & Therapy: Background FDG-PET hypometabolism patterns are indicative of different neurodegenerative conditions, even from the earliest disease phase. This makes FDG-PET a valuable tool...

A modular analysis of microglia gene expression, insights into the aged...

Genomics: Background Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of the...

A case of methylprednisolone treatment for metronidazole-induced encephalopathy

Neurology Background: Metronidazole, a common antimicrobial agent, can induce encephalopathy in rare cases. After discontinuing metronidazole, most patients show clinical improvement. However, in...

Managing emerging transnational public health security threats: lessons learned from the...

Globalization and Health: Background Pandemics pose significant security/stability risks to nations with...

HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

Medical Genetics: Background HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is relevant to establish resistance to therapeutic approaches. The use of compounds direct against hypoxia signaling...

Delay in antibiotic therapy results in fatal disease outcome in murine...

Critical Care: Background Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are...

Dual-phase whole-heart imaging using image navigation in congenital heart disease

Medical Imaging: Background Dual-phase 3-dimensional whole-heart acquisition allows simultaneous imaging during systole and diastole. Respiratory navigator gating and tracking of the diaphragm is used with limited...

T cell dynamics and response of the microbiota after gene therapy...

Genome Medicine: Background Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene...

Transcranial direct current stimulation for the treatment of tinnitus: a review...

Neuroscience: Background Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous...

Fibronectin type III domain-containing protein 5 interacts with APP and decreases...

Molecular Brain: The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism...

Trends analysis for drug utilization in county public hospitals: a sample...

Health Services Research: Background Changes in the national drug policy always have impact on the drug utilization. In the context of China health care reform, what...

Structural and procedural barriers to health assessment for asylum seekers and...

Health Services Research: Background Health assessments (HAs) for newly arrived asylum seekers have become a regular practice in most EU countries, but what is performed, how...

Exploring the OncoGenomic Landscape of cancer

Genome Medicine: Background The widespread incorporation of next-generation sequencing into clinical oncology has yielded an unprecedented amount of molecular data from thousands of patients. A main...

New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis...

Genomics: Background Ural genetic family is a part of the Euro-American lineage of Mycobacterium tuberculosis and is endemic in Northern Eurasia (former Soviet Union ). These strains were...

Identification of a novel DNMT1 mutation in a Chinese patient with...

Neurology: DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It...

Functional EEG connectivity during competition

Neuroscience: Background Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since...

The impact of education on cortical thickness in amyloid-negative subcortical vascular...

Alzheimer's Research Background The protective effect of education has been well established in Alzheimer’s disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear....

MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker...

Alzheimer's Research Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers...

Complete genome sequence of Kocuria rhizophila BT304, isolated from the small...

Genome Background Members of the species Kocuria rhizophila, belonging to the family Micrococcaceae in the phylum Actinobacteria, have been isolated from a wide variety of natural...

Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in...

ImmunoTherapy of Cancer Background Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical...

Biochemical and molecular characterization of adult patients with type I Gaucher...

Medical Genetics Background Gaucher disease is a rare pan-ethnic disorder which occurs due to an increased accumulation of undegraded glycolipid glucocerebroside inside the cells’ lysosomes. A...

Protein interaction and functional data indicate MTHFD2 involvement in RNA processing...

Cancer & Metabolism: Background The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as...

Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway...

Immunology Background The involvement of inflammasome activation and macrophage polarization during the process of syphilis infection remains unknown. In this study, A series of experiments were...

Emotion regulation and its relation to symptoms of anxiety and depression...

Psychology Background Symptoms of anxiety and depression are prevalent and highly comorbid in children, contributing to considerable impairment even at a subclinical level. Difficulties with emotion...