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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV)...

© Author(s) Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong & Gengfu...

Psychosocial impact of prognostic genetic testing in uveal melanoma patients: a...

Abstract Background The risk of metastases in uveal melanoma can accurately be estimated through genetic analysis of the tumor. A growing number of patients decide to...

Fluoxetine-induced dematuration of hippocampal neurons and adult cortical neurogenesis in the...

Molecular Brain: Abstract The selective serotonin reuptake inhibitor fluoxetine (FLX) is widely...

Investigation of PLGA nanoparticles in conjunction with nuclear localization sequence for...

Nanobiotechnology:Numerous first generation phosphorothioates (PS) and their derivatives have shown promise targeting mRNA for therapeutic applications and also gained market approval for their use...

Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria

Alzheimer's Research & Therapy: Background FDG-PET hypometabolism patterns are indicative of different neurodegenerative conditions, even from the earliest disease phase. This makes FDG-PET a valuable tool...

A modular analysis of microglia gene expression, insights into the aged...

Genomics: Background Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of the...

Detection of gastric cancer and its histological type based on iodine...

Cancer Imaging: Background Computed tomography (CT) imaging is the most common imaging modality for the diagnosis and staging of gastric cancer. The aim of this study...

Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal...

Biomedical Science: Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors...

Suicide rates in Crete, Greece during the economic crisis: the effect...

Psychiatry | Psychology: Background Recently, suicides in Greece have drawn national and international interest due to the current economic crisis. According to published reports, suicides in...

Delay in antibiotic therapy results in fatal disease outcome in murine...

Critical Care: Background Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are...

Dual-phase whole-heart imaging using image navigation in congenital heart disease

Medical Imaging: Background Dual-phase 3-dimensional whole-heart acquisition allows simultaneous imaging during systole and diastole. Respiratory navigator gating and tracking of the diaphragm is used with limited...

T cell dynamics and response of the microbiota after gene therapy...

Genome Medicine: Background Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene...

Transcranial direct current stimulation for the treatment of tinnitus: a review...

Neuroscience: Background Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous...

Fibronectin type III domain-containing protein 5 interacts with APP and decreases...

Molecular Brain: The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism...

Trends analysis for drug utilization in county public hospitals: a sample...

Health Services Research: Background Changes in the national drug policy always have impact on the drug utilization. In the context of China health care reform, what...

Exploring the OncoGenomic Landscape of cancer

Genome Medicine: Background The widespread incorporation of next-generation sequencing into clinical oncology has yielded an unprecedented amount of molecular data from thousands of patients. A main...

New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis...

Genomics: Background Ural genetic family is a part of the Euro-American lineage of Mycobacterium tuberculosis and is endemic in Northern Eurasia (former Soviet Union ). These strains were...

Effects on the pulmonary hemodynamics and gas exchange with a speed...

Engineering OnLine: Rotary blood pumps (RBPs) are the newest generation of ventricular assist devices. Although their continuous flow characteristics have been accepted widely, more and...

Identification of a novel DNMT1 mutation in a Chinese patient with...

Neurology: DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It...

Functional EEG connectivity during competition

Neuroscience: Background Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since...

The impact of education on cortical thickness in amyloid-negative subcortical vascular...

Alzheimer's Research Background The protective effect of education has been well established in Alzheimer’s disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear....

MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker...

Alzheimer's Research Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers...

Complete genome sequence of Kocuria rhizophila BT304, isolated from the small...

Genome Background Members of the species Kocuria rhizophila, belonging to the family Micrococcaceae in the phylum Actinobacteria, have been isolated from a wide variety of natural...

Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in...

ImmunoTherapy of Cancer Background Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical...

Biochemical and molecular characterization of adult patients with type I Gaucher...

Medical Genetics Background Gaucher disease is a rare pan-ethnic disorder which occurs due to an increased accumulation of undegraded glycolipid glucocerebroside inside the cells’ lysosomes. A...