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Modifiable dementia risk score to study heterogeneity in treatment effect of...

Alzheimer's Research & Therapy Abstract Background Selecting high-risk participants for dementia prevention trials based on a modifiable dementia risk score may be advantageous, as it increases the...

Effectiveness of a diabetes prevention program for rural women with prior...

Public Health Abstract Background In China, about 53.4 million women (11%) have type 2 diabetes (T2DM). Women with prior 2 (GDM) are at a high risk for...

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline...

Behavioral and Brain Functions Abstract Background With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life....

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures

Molecular Brain Abstract Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these...

Cellular stress response mechanisms of Rhizoma coptidis: a systematic review

Chinese Medicine Abstract Rhizoma coptidis has been used in China for thousands of years with the functions of heating dampness and purging fire detoxification. But the...

The impact of blood type O on mortality of severe trauma...

Critical Care Abstract Background Recent studies have implicated the differences in the ABO blood system as a potential risk for various diseases, including hemostatic disorders and hemorrhage....

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The effect for Japanese workers of a self-help computerized cognitive behaviour...

Psychology: Abstract Background Computerized cognitive behaviour therapy (CCBT) programs can provide a useful self-help approach to the treatment of psychological problems. Previous studies have shown that CCBT...

The effect of recall, reproduction, and restudy on word learning: a...

Psychology: Abstract Background Certain manipulations, such as testing oneself on newly learned word associations (recall), or the act of repeating a word during training (reproduction), can lead...

Consequences of child emotional abuse, emotional neglect and exposure to intimate...

Psychology: Abstract Background Child maltreatment and eating disorders are significant public health problems. Yet, to date, research has focused on the role of child physical and sexual...

Tracking progressive pathological and functional decline in the rTg4510 mouse model...

Alzheimer's Research & Therapy: Abstract Background The choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical translation...

Effects of dosimetric inadequacy on local control and toxicities in the...

Chinese Journal of Cancer: Abstract Background To protect neurological tissues, underdosing occurs in most cases of T4 nasopharyngeal carcinoma (NPC) with intracranial extension. In this study, we...

Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is...

Cancer Cells: Abstract Objective To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived exosomes. Methods Exosomes...

The association of sleep disordered breathing with left ventricular remodeling in...

Cardiovascular Disorders: Abstract Background There is still insufficient knowledge on the potential effect of mild to moderate sleep-disordered breathing (SDB) that is widely prevalent, often asymptomatic, and...

Selective impairments of alerting and executive control in HIV-infected patients: evidence...

Behavioral and Brain Functions: Abstract: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has...

Molecular chess? Hallmarks of anti-cancer drug resistance

Abstract Background The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is...

Does Congenital Deafness Affect the Structural and Functional Architecture of Primary...

Abstract Deafness results in greater reliance on the remaining senses. It is unknown whether the cortical architecture of the intact senses is optimized to compensate...

Skeleton-based cerebrovascular quantitative analysis

Xingce Wang, Enhui Liu†, Zhongke Wu, Feifei Zhai†, Yi-Cheng Zhu, Wuyang Shui and Mingquan Zhou ©  The Author(s) 2016 Abstract Background Cerebrovascular disease is the most common cause of death worldwide, with millions of deaths annually. Interest is increasing toward understanding the...

Quantitative analysis of axon collaterals of single pyramidal cells of the...

Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda,Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda © The Author(s) 2017 Abstract Background The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the...

A functional magnetic resonance imaging investigation of visual hallucinations in the...

Behavioral and Brain Functions Hina Abid, Fayyaz Ahmad, Soo Y. Lee, Hyun W. Park, Dongmi Im, Iftikhar Ahmad and Safee U. Chaudhary | ©  The Author(s) 2016 Abstract Purpose Human beings frequently experience fear, phobia, migraine and hallucinations, however, the cerebral mechanisms underpinning these conditions...

Integrated therapy for HIV and tuberculosis

Abstract Tuberculosis (TB) has been the most common opportunistic infection and cause of mortality among HIV-infected patients, especially in resource-limited countries. Clinical manifestations of TB...

Transient left atrial dysfunction is a feature of Takotsubo syndrome

Abstract Background Takotsubo syndrome (TTS) is characterized by a transient left and/or right ventricular dysfunction as a consequence of a distinctive pattern of regional wall motion...

Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in...

Abstract Substantial data indicate that amyloid-β (Aβ), the major component of senile plaques, plays a central role in Alzheimer’s Disease and indeed the assembly of...

Review of RyR1 pathway and associated pathomechanisms

Abstract Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle important for excitation-contraction coupling. Mutations in the RYR1 gene yield RyR1 protein...

Scripps Florida Scientists Identify Novel Compound to Alleviate Pain and Itch

In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a possible drug candidate that suppresses pain...

Environmental scientist’s early warning indicators win the prize

Promising environmental researcher David Seekell has been awarded a prestigious prize: the Science and SciLifeLab Prize for Young Scientists. He was awarded the prize...