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Endometrial cancer: an overview of novelties in treatment and related imaging...

Cancer Imaging: Endometrial cancer is the most common gynaecologic malignancy in developed countries and its incidence is increasing. First-level treatment, if no contraindicated, is based...

Epidemiology of mechanically ventilated patients treated in ICU and non-ICU settings...

Critical Care: Background In most countries, patients receiving mechanical ventilation (MV) are treated in intensive care units (ICUs). However, in some countries, including Japan, many patients...

Adaptive filtering of physiological noises in fNIRS data

BioMedical Engineering: The study presents a recursive least-squares estimation method with an exponential forgetting factor for noise removal in functional near-infrared spectroscopy data and extraction...

Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/β-catenin...

Nanobiotechnology: Background Fabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention. Methods In a previous study, novel lanthanum phosphate...

Identification of novel compound heterozygous SPG7 mutations-related hereditary spastic paraplegia in...

Neurology: Background Autosomal recessive hereditary spastic paraplegias (ARHSPs) are a group of clinically and genetically heterogeneous neurodegenerative diseases with progressive spasticity and weakness in the lower...

Performance comparison of ventricular and arterial dP/dtmax for assessing left ventricular...

Critical Care: Background Maximal left ventricular (LV) pressure rise (LV dP/dtmax), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform...

The impact of education on cortical thickness in amyloid-negative subcortical vascular...

Alzheimer's Research Background The protective effect of education has been well established in Alzheimer’s disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear....

MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker...

Alzheimer's Research Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers...

Complete genome sequence of Kocuria rhizophila BT304, isolated from the small...

Genome Background Members of the species Kocuria rhizophila, belonging to the family Micrococcaceae in the phylum Actinobacteria, have been isolated from a wide variety of natural...

Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in...

ImmunoTherapy of Cancer Background Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical...

Biochemical and molecular characterization of adult patients with type I Gaucher...

Medical Genetics Background Gaucher disease is a rare pan-ethnic disorder which occurs due to an increased accumulation of undegraded glycolipid glucocerebroside inside the cells’ lysosomes. A...

Protein interaction and functional data indicate MTHFD2 involvement in RNA processing...

Cancer & Metabolism: Background The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as...

Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway...

Immunology Background The involvement of inflammasome activation and macrophage polarization during the process of syphilis infection remains unknown. In this study, A series of experiments were...

Emotion regulation and its relation to symptoms of anxiety and depression...

Psychology Background Symptoms of anxiety and depression are prevalent and highly comorbid in children, contributing to considerable impairment even at a subclinical level. Difficulties with emotion...

Horizontal transfer of BovB and L1 retrotransposons in eukaryotes

Genome Biology Background Transposable elements (TEs) are mobile DNA sequences, colloquially known as jumping genes because of their ability to replicate to new genomic locations. TEs...

Sepsis is a preventable public health problem

Critical Care There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments...

Criminal justice measures for economic data harmonization in substance use disorder...

Health & Justice Background The consequences of substance use disorders (SUDs) are varied and broad, affecting many sectors of society and the economy. Economic evaluation translates...

Anti-inflammatory effects of minocycline are mediated by retinoid signaling

Neuroscience: Background Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data...

Low-cost customized cranioplasty using a 3D digital printing model: a case...

3D Printing in Medicine Abstract Background Cranial defects usually occur after trauma, neurosurgical procedures like decompressive craniotomy, tumour resections, infection and congenital defects. The purpose of cranial...

Utilizing a low-cost desktop 3D printer to develop a “one-stop 3D...

3D Printing in Medicine Abstract Background In the oral and maxillofacial surgery and dentistry fields, the use of three-dimensional (3D) patient-specific organ models is increasing, which has...

How group singing facilitates recovery from the symptoms of postnatal depression:...

Psychology Abstract Background Previous research has demonstrated that making music can enhance positive emotions as well as support positive psychological functioning. However, studies tend to be limited...

Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients...

Alzheimer's Research & Therapy Abstract Background Increasing evidence suggests that cerebral vascular dysfunction is associated with the early stages of Alzheimer’s disease (AD). Vascular endothelial growth factor...

Modifiable dementia risk score to study heterogeneity in treatment effect of...

Alzheimer's Research & Therapy Abstract Background Selecting high-risk participants for dementia prevention trials based on a modifiable dementia risk score may be advantageous, as it increases the...

Effectiveness of a diabetes prevention program for rural women with prior...

Public Health Abstract Background In China, about 53.4 million women (11%) have type 2 diabetes (T2DM). Women with prior 2 (GDM) are at a high risk for...

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline...

Behavioral and Brain Functions Abstract Background With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life....