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Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal...

Biomedical Science: Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the interaction of genetic, environmental, barrier and microbial factors...

Suicide rates in Crete, Greece during the economic crisis: the effect...

Psychiatry | Psychology: Background Recently, suicides in Greece have drawn national and international interest due to the current economic crisis. According to published reports, suicides in...

Delay in antibiotic therapy results in fatal disease outcome in murine...

Critical Care: Background Community-acquired pneumonia (CAP) remains a major cause of death worldwide. Mechanisms underlying the detrimental outcome despite adequate antibiotic therapy and comorbidity management are...

Dual-phase whole-heart imaging using image navigation in congenital heart disease

Medical Imaging: Background Dual-phase 3-dimensional whole-heart acquisition allows simultaneous imaging during systole and diastole. Respiratory navigator gating and tracking of the diaphragm is used with limited...

T cell dynamics and response of the microbiota after gene therapy...

Genome Medicine: Background Mutation of the IL2RG gene results in a form of severe combined immune deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene...

Transcranial direct current stimulation for the treatment of tinnitus: a review...

Neuroscience: Background Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous...

Emotion regulation and its relation to symptoms of anxiety and depression...

Psychology Background Symptoms of anxiety and depression are prevalent and highly comorbid in children, contributing to considerable impairment even at a subclinical level. Difficulties with emotion...

Horizontal transfer of BovB and L1 retrotransposons in eukaryotes

Genome Biology Background Transposable elements (TEs) are mobile DNA sequences, colloquially known as jumping genes because of their ability to replicate to new genomic locations. TEs...

Functional characterization of enhancer evolution in the primate lineage

Genome Biology Background Enhancers play an important role in morphological evolution and speciation by controlling the spatiotemporal expression of genes. Previous efforts to understand the evolution...

Sepsis is a preventable public health problem

Critical Care There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments...

Criminal justice measures for economic data harmonization in substance use disorder...

Health & Justice Background The consequences of substance use disorders (SUDs) are varied and broad, affecting many sectors of society and the economy. Economic evaluation translates...

Anti-inflammatory effects of minocycline are mediated by retinoid signaling

Neuroscience: Background Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data...

Low-cost customized cranioplasty using a 3D digital printing model: a case...

3D Printing in Medicine Abstract Background Cranial defects usually occur after trauma, neurosurgical procedures like decompressive craniotomy, tumour resections, infection and congenital defects. The purpose of cranial...

Utilizing a low-cost desktop 3D printer to develop a “one-stop 3D...

3D Printing in Medicine Abstract Background In the oral and maxillofacial surgery and dentistry fields, the use of three-dimensional (3D) patient-specific organ models is increasing, which has...

How group singing facilitates recovery from the symptoms of postnatal depression:...

Psychology Abstract Background Previous research has demonstrated that making music can enhance positive emotions as well as support positive psychological functioning. However, studies tend to be limited...

Modifiable dementia risk score to study heterogeneity in treatment effect of...

Alzheimer's Research & Therapy Abstract Background Selecting high-risk participants for dementia prevention trials based on a modifiable dementia risk score may be advantageous, as it increases the...

Effectiveness of a diabetes prevention program for rural women with prior...

Public Health Abstract Background In China, about 53.4 million women (11%) have type 2 diabetes (T2DM). Women with prior 2 (GDM) are at a high risk for...

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline...

Behavioral and Brain Functions Abstract Background With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life....

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures

Molecular Brain Abstract Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these...

Cellular stress response mechanisms of Rhizoma coptidis: a systematic review

Chinese Medicine Abstract Rhizoma coptidis has been used in China for thousands of years with the functions of heating dampness and purging fire detoxification. But the...

The impact of blood type O on mortality of severe trauma...

Critical Care Abstract Background Recent studies have implicated the differences in the ABO blood system as a potential risk for various diseases, including hemostatic disorders and hemorrhage....

Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in...

Chinese Medicine Abstract Background To evaluate the effect of Isorhynchophylline (IRN) on the learning and memory impairments induced by aluminum chloride (AlCl3) in mice. Methods Fifty male Balb-c mice...

Characterisation of Zika virus infection in primary human astrocytes

Neuroscience Abstract Background The recent Zika virus (ZIKV) outbreak has linked ZIKV with microcephaly and other central nervous system pathologies in humans. Astrocytes are among the first...

An integrative functional genomics framework for effective identification of novel regulatory...

Genome Medicine Abstract Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A...

InsP3R-SEC5 interaction on phagosomes modulates innate immunity to Candida albicans by...

Biology Abstract Background Candida albicans (C. albicans) invasion triggers antifungal innate immunity, and the elevation of cytoplasmic Ca2+ levels via the inositol 1,4,5-trisphosphate receptor (InsP3R) plays a...