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Medicine

Protein interaction and functional data indicate MTHFD2 involvement in RNA processing...

Cancer & Metabolism: Background The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as...

Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway...

Immunology Background The involvement of inflammasome activation and macrophage polarization during the process of syphilis infection remains unknown. In this study, A series of experiments were...

Horizontal transfer of BovB and L1 retrotransposons in eukaryotes

Genome Biology Background Transposable elements (TEs) are mobile DNA sequences, colloquially known as jumping genes because of their ability to replicate to new genomic locations. TEs...

Functional characterization of enhancer evolution in the primate lineage

Genome Biology Background Enhancers play an important role in morphological evolution and speciation by controlling the spatiotemporal expression of genes. Previous efforts to understand the evolution...

Sepsis is a preventable public health problem

Critical Care There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments...

Anti-inflammatory effects of minocycline are mediated by retinoid signaling

Neuroscience: Background Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data...

Low-cost customized cranioplasty using a 3D digital printing model: a case...

3D Printing in Medicine Abstract Background Cranial defects usually occur after trauma, neurosurgical procedures like decompressive craniotomy, tumour resections, infection and congenital defects. The purpose of cranial...

Utilizing a low-cost desktop 3D printer to develop a “one-stop 3D...

3D Printing in Medicine Abstract Background In the oral and maxillofacial surgery and dentistry fields, the use of three-dimensional (3D) patient-specific organ models is increasing, which has...

Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients...

Alzheimer's Research & Therapy Abstract Background Increasing evidence suggests that cerebral vascular dysfunction is associated with the early stages of Alzheimer’s disease (AD). Vascular endothelial growth factor...

Modifiable dementia risk score to study heterogeneity in treatment effect of...

Alzheimer's Research & Therapy Abstract Background Selecting high-risk participants for dementia prevention trials based on a modifiable dementia risk score may be advantageous, as it increases the...

Effectiveness of a diabetes prevention program for rural women with prior...

Public Health Abstract Background In China, about 53.4 million women (11%) have type 2 diabetes (T2DM). Women with prior 2 (GDM) are at a high risk for...

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline...

Behavioral and Brain Functions Abstract Background With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life....

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures

Molecular Brain Abstract Microglia have been shown to be of critical importance to the progression of temporal lobe epilepsy. However, the broad transcriptional changes that these...

Cellular stress response mechanisms of Rhizoma coptidis: a systematic review

Chinese Medicine Abstract Rhizoma coptidis has been used in China for thousands of years with the functions of heating dampness and purging fire detoxification. But the...

The impact of blood type O on mortality of severe trauma...

Critical Care Abstract Background Recent studies have implicated the differences in the ABO blood system as a potential risk for various diseases, including hemostatic disorders and hemorrhage....

Isorhynchophylline alleviates learning and memory impairments induced by aluminum chloride in...

Chinese Medicine Abstract Background To evaluate the effect of Isorhynchophylline (IRN) on the learning and memory impairments induced by aluminum chloride (AlCl3) in mice. Methods Fifty male Balb-c mice...

Characterisation of Zika virus infection in primary human astrocytes

Neuroscience Abstract Background The recent Zika virus (ZIKV) outbreak has linked ZIKV with microcephaly and other central nervous system pathologies in humans. Astrocytes are among the first...

An integrative functional genomics framework for effective identification of novel regulatory...

Genome Medicine Abstract Background Genome–phenome studies have identified thousands of variants that are statistically associated with disease or traits; however, their functional roles are largely unclear. A...

Role of the HIV-1 envelope transmembrane domain in intracellular sorting

Cell Biology Abstract Background The envelope protein of lentiviruses are type I transmembrane proteins, and their transmembrane domain contains conserved potentially charged residues. This highly unusual feature...

Mitochondrial dysfunction and autism: comprehensive genetic analyses of children with autism...

Behavioral and Brain Functions Abstract Background The etiology of autism spectrum disorders (ASD) is very heterogeneous. Mitochondrial dysfunction has been described in ASD; however, primary mitochondrial disease...

Neural correlates of interference resolution in the multi-source interference task: a...

Behavioral and Brain Functions Abstract Background Interference resolution refers to cognitive control processes enabling one to focus on task-related information while filtering out unrelated information. But the...

Integrative bioinformatics analysis characterizing the role of EDC3 in mRNA decay...

Abstract Background Decapping of mRNA is an important step in the regulation of mRNA turnover and therefore of gene expression, which is a key process controlling...

Cancer Genome Interpreter annotates the biological and clinical relevance of tumor...

Genome Medicine Abstract While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck....

Tracking progressive pathological and functional decline in the rTg4510 mouse model...

Alzheimer's Research & Therapy: Abstract Background The choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical translation...