Transcranial direct current stimulation for the treatment of tinnitus: a review...
Neuroscience:
Background
Tinnitus is the perception of sound in the absence of any external acoustic stimulation. Transcranial direct current stimulation (tDCS) has shown promising though heterogeneous...
Fibronectin type III domain-containing protein 5 interacts with APP and decreases...
Molecular Brain:
The deposition of Amyloid-beta peptides (Aβ) is detected at an earlier stage in Alzheimer’s disease (AD) pathology. Thus, the approach toward Aβ metabolism...
Trends analysis for drug utilization in county public hospitals: a sample...
Health Services Research:
Background
Changes in the national drug policy always have impact on the drug utilization. In the context of China health care reform, what...
Structural and procedural barriers to health assessment for asylum seekers and...
Health Services Research:
Background
Health assessments (HAs) for newly arrived asylum seekers have become a regular practice in most EU countries, but what is performed, how...
Exploring the OncoGenomic Landscape of cancer
Genome Medicine:
Background
The widespread incorporation of next-generation sequencing into clinical oncology has yielded an unprecedented amount of molecular data from thousands of patients. A main...
New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis...
Genomics:
Background
Ural genetic family is a part of the Euro-American lineage of Mycobacterium tuberculosis and is endemic in Northern Eurasia (former Soviet Union ). These strains were...
Effects on the pulmonary hemodynamics and gas exchange with a speed...
Engineering OnLine:
Rotary blood pumps (RBPs) are the newest generation of ventricular assist devices. Although their continuous flow characteristics have been accepted widely, more and...
Identification of a novel DNMT1 mutation in a Chinese patient with...
Neurology:
DNA methyltransferase 1 (EC 2.1.1.37), encoded by DNMT1 gene, is one of key enzymes in maintaining DNA methylation patterns of the human genome. It...
Functional EEG connectivity during competition
Neuroscience:
Background
Social behavior and interactions pervasively shape and influence our lives and relationships. Competition, in particular, has become a core topic in social neuroscience since...
The impact of education on cortical thickness in amyloid-negative subcortical vascular...
Alzheimer's Research
Background
The protective effect of education has been well established in Alzheimer’s disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear....
MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker...
Alzheimer's Research
Background
With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers...
Complete genome sequence of Kocuria rhizophila BT304, isolated from the small...
Genome
Background
Members of the species Kocuria rhizophila, belonging to the family Micrococcaceae in the phylum Actinobacteria, have been isolated from a wide variety of natural...
Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in...
ImmunoTherapy of Cancer
Background
Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical...
Biochemical and molecular characterization of adult patients with type I Gaucher...
Medical Genetics
Background
Gaucher disease is a rare pan-ethnic disorder which occurs due to an increased accumulation of undegraded glycolipid glucocerebroside inside the cells’ lysosomes. A...
Protein interaction and functional data indicate MTHFD2 involvement in RNA processing...
Cancer & Metabolism:
Background
The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and is therefore of interest as...
Treponema pallidum promotes macrophage polarization and activates the NLRP3 inflammasome pathway...
Immunology
Background
The involvement of inflammasome activation and macrophage polarization during the process of syphilis infection remains unknown. In this study, A series of experiments were...
Horizontal transfer of BovB and L1 retrotransposons in eukaryotes
Genome Biology
Background
Transposable elements (TEs) are mobile DNA sequences, colloquially known as jumping genes because of their ability to replicate to new genomic locations. TEs...
Functional characterization of enhancer evolution in the primate lineage
Genome Biology
Background
Enhancers play an important role in morphological evolution and speciation by controlling the spatiotemporal expression of genes. Previous efforts to understand the evolution...
Sepsis is a preventable public health problem
Critical Care
There is a paradigm shift happening for sepsis. Sepsis is no longer solely conceptualized as problem of individual patients treated in emergency departments...
Anti-inflammatory effects of minocycline are mediated by retinoid signaling
Neuroscience:
Background
Minocycline is a lipophilic tetracycline of increasing appeal in neuroscience as it inhibits microglial activation, a mechanism involved in numerous neuropsychiatric disorders. Own data...
Low-cost customized cranioplasty using a 3D digital printing model: a case...
3D Printing in Medicine
Abstract
Background
Cranial defects usually occur after trauma, neurosurgical procedures like decompressive craniotomy, tumour resections, infection and congenital defects. The purpose of cranial...
Utilizing a low-cost desktop 3D printer to develop a “one-stop 3D...
3D Printing in Medicine
Abstract
Background
In the oral and maxillofacial surgery and dentistry fields, the use of three-dimensional (3D) patient-specific organ models is increasing, which has...
Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients...
Alzheimer's Research & Therapy
Abstract
Background
Increasing evidence suggests that cerebral vascular dysfunction is associated with the early stages of Alzheimer’s disease (AD). Vascular endothelial growth factor...
Modifiable dementia risk score to study heterogeneity in treatment effect of...
Alzheimer's Research & Therapy
Abstract
Background
Selecting high-risk participants for dementia prevention trials based on a modifiable dementia risk score may be advantageous, as it increases the...