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Medicine

Suppression of endothelial cell migration by tumor associated macrophage-derived exosomes is...

Cancer Cells: Abstract Objective To study the mechanism by which epithelial ovarian cancer (EOC)-derived exosomes restore the migration of endothelial cells that is suppressed by TAM-derived exosomes. Methods Exosomes...

The association of sleep disordered breathing with left ventricular remodeling in...

Cardiovascular Disorders: Abstract Background There is still insufficient knowledge on the potential effect of mild to moderate sleep-disordered breathing (SDB) that is widely prevalent, often asymptomatic, and...

Selective impairments of alerting and executive control in HIV-infected patients: evidence...

Behavioral and Brain Functions: Abstract: Attention ability can be subdivided into three functionally independent networks, i.e., alerting network, orienting network, and executive network. Previous literature has...

Molecular chess? Hallmarks of anti-cancer drug resistance

Abstract Background The development of resistance is a problem shared by both classical chemotherapy and targeted therapy. Patients may respond well at first, but relapse is...

Microparticles shed from multidrug resistant breast cancer cells provide a parallel...

Abstract Background Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune...

Does Congenital Deafness Affect the Structural and Functional Architecture of Primary...

Abstract Deafness results in greater reliance on the remaining senses. It is unknown whether the cortical architecture of the intact senses is optimized to compensate...

Skeleton-based cerebrovascular quantitative analysis

Xingce Wang, Enhui Liu†, Zhongke Wu, Feifei Zhai†, Yi-Cheng Zhu, Wuyang Shui and Mingquan Zhou ©  The Author(s) 2016 Abstract Background Cerebrovascular disease is the most common cause of death worldwide, with millions of deaths annually. Interest is increasing toward understanding the...

Quantitative analysis of axon collaterals of single pyramidal cells of the...

Junli Yang, Gerhard Litscher, Zhongren Sun, Qiang Tang, Kiyoshi Kishi, Satoko Oda,Masaaki Takayanagi, Zemin Sheng, Yang Liu, Wenhai Guo, Ting Zhang, Lu Wang, Ingrid Gaischek, Daniela Litscher, Irmgard Th. Lippe and Masaru Kuroda © The Author(s) 2017 Abstract Background The role of the piriform cortex (PC) in olfactory information processing remains largely unknown. The anterior part of the...

Integrated therapy for HIV and tuberculosis

Abstract Tuberculosis (TB) has been the most common opportunistic infection and cause of mortality among HIV-infected patients, especially in resource-limited countries. Clinical manifestations of TB...

Transient left atrial dysfunction is a feature of Takotsubo syndrome

Abstract Background Takotsubo syndrome (TTS) is characterized by a transient left and/or right ventricular dysfunction as a consequence of a distinctive pattern of regional wall motion...

Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in...

Abstract Substantial data indicate that amyloid-β (Aβ), the major component of senile plaques, plays a central role in Alzheimer’s Disease and indeed the assembly of...

Review of RyR1 pathway and associated pathomechanisms

Abstract Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle important for excitation-contraction coupling. Mutations in the RYR1 gene yield RyR1 protein...

Scripps Florida Scientists Identify Novel Compound to Alleviate Pain and Itch

In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a possible drug candidate that suppresses pain...

Environmental scientist’s early warning indicators win the prize

Promising environmental researcher David Seekell has been awarded a prestigious prize: the Science and SciLifeLab Prize for Young Scientists. He was awarded the prize...

Short-term memory is based on synchronized brain oscillations

Scientists have now discovered how different brain regions cooperate during short-term memory. Holding information within one’s memory for a short while is a seemingly...

Improving Medical Treatment Requires a Risk-based Approach to the Regulation of...

Current EU legislation represents a major hurdle to improving medical treatment due to the straight-jacket of EU legislation that the 2001 Clinical Trials Directive...

Barrett’s patients who smoke twice as likely to develop oesophageal cancer

Smoking doubles the risk of developing oesophageal cancer in people with Barrett’s Oesophagus, according to scientists at Queen’s University Belfast and the Northern Ireland...

In lab, Pannexin1 restores tight binding of cells that is lost...

By studying tumor cell behavior in a novel “scaffold-free” 3-D system, researchers have determined that the protein Pannexin1 may play an important biomechanical role...

Oxygen molecule survives to enormously high pressures

Using computer simulations, a RUB researcher has shown that the oxygen molecule (O2) is stable up to pressures of 1.9 terapascal, which is about...

Neue Aufgaben für Aurora-Proteine bei der Zellteilung

Erkenntnisse bei Spalthefe geben Hinweise für die Erforschung von Krebstherapien. Wenn eine Zelle sich teilt, muss die Erbinformation in den Chromosomen fehlerfrei an die...

Genes influence memory and sense of orientation

How do our brains process memory and sense of orientation? Scientists are gaining insight by studying rats with implanted genes that prompt neurons to...

Scientists investigate whether a blood test can help to detect breast...

A study spearheaded by the University of Leicester aims to find out whether a blood test can detect cancer, earlier than current methods, in...

Wichtiges Überlebenssignal in aggressiven Lymphomen entdeckt

Wissenschaftlern des Helmholtz Zentrums München in Zusammenarbeit mit der Charité-Universitätsmedizin Berlin ist es gelungen, einen essentiellen Baustein für das Überleben einer Untergruppe von bösartigen...

Glioblastom: Impfstoff verlängert bei jedem dritten Patienten die Überlebenszeit

Patienten mit Hirntumoren (Glioblastom), bei denen das Krebsgen EGFRvIII nachgewiesen wird, überleben doppelt so lang, wenn sie mit einer neu entwickelten Tumorimpfung behandelt werden....